Title
Integrated microRNA and mRNA expression profile analysis of tumor-associated macrophages after exposure to single-dose irradiation.
Abstract
We established a murine model irradiated with a single dose of 25 Gy that could initiate temporal changes in the expression of miRNAs associated with cell proliferation and the immune response, as evidenced by macrophages directly extracted from irradiated tumors after two weeks of IR. Statistical analyses were conducted by comparing the miRNA expression in macrophages from non-irradiated versus irradiated tumors. Thus, our study could lead to a better understanding of the function of miRNA expressions, which changed temporally in an irradiated tumor microenvironment.
Year
DOI
Venue
2018
10.1016/j.compbiolchem.2018.03.016
Computational Biology and Chemistry
Keywords
Field
DocType
Tumor-associated macrophages,Tumor microenvironment,Microarray,microRNA,microRNA target interaction (MTI)
Tumor microenvironment,Tumor progression,Microarray,Biology,microRNA,Cancer research,Radiation therapy,Immune system,Bioinformatics,Cancer,Gene expression profiling
Journal
Volume
ISSN
Citations 
74
1476-9271
0
PageRank 
References 
Authors
0.34
1
7
Name
Order
Citations
PageRank
Wei-Hsiang Kung110.96
Andy Chi-Lung Lee200.34
Chi-dung Yang3844.79
Ching-Fang Yu410.96
Men-Yee Chiew5171.44
Fang-Hsin Chen611.30
Hsien-Da Huang783563.83