Paper Info
Title
Dynamic functional connectivity and its behavioral correlates beyond vigilance.
Abstract
Fluctuations in resting-state functional connectivity and global signal have been found to correspond with vigilance fluctuations, but their associations with other behavioral measures are unclear. We evaluated 52 healthy adolescents after a week of adequate sleep followed by five nights of sleep restriction to unmask inter-individual differences in cognition and mood. Resting state scans obtained at baseline only, analyzed using sliding window analysis, consistently yielded two polar dynamic functional connectivity states (DCSs) corresponding to previously reported ‘low arousal’ and ‘high arousal’ states. We found that the relative temporal preponderance of two dynamic connectivity states (DCS) in well-rested participants, indexed by a median split of participants, based on the relative time spent in these DCS, revealed highly significant group differences in vigilance at baseline and its decline following multiple nights of sleep restriction. Group differences in processing speed and working memory following manipulation but not at baseline suggest utility of DCS in predicting cognitive vulnerabilities unmasked by a stressor like sleep restriction. DCS temporal predominance was uninformative about mood and sleepiness speaking to specificity in its behavioral predictions. Global signal fluctuation provided information confined to vigilance. This appears to be related to head motion, which increases during periods of low arousal.
Year
DOI
Venue
2018
10.1016/j.neuroimage.2018.04.049
NeuroImage
Keywords
Field
DocType
Vigilance,Speed of processing,Working memory,Sleep deprivation,Dynamic functional connectivity (fMRI),Global signal
Low arousal theory,Mood,Arousal,Resting state fMRI,Psychology,Cognitive psychology,Vigilance (psychology),Sleep restriction,Sleep deprivation,Audiology,Dynamic functional connectivity
Journal
Volume
ISSN
Citations 
177
1053-8119
4
PageRank 
References 
Authors
0.41
11
6
Name
Order
Citations
PageRank
Amiya Patanaik161.45
Jesisca Tandi2442.91
Ju Lynn Ong3314.45
Chen-Hao Wang42114.23
Juan Zhou5834.71
Michael W. L. Chee627926.13