Title
Large-Scale Continuous Mobility Monitoring of Parkinson's Disease Patients Using Smartphones.
Abstract
Smartphone-based assessments have been considered a potential solution for continuously monitoring gait and mobility in mild to moderate Parkinson's disease (PD) patients. Forty-four PD patients from cohorts 4 to 6 of the Multiple Ascending Dose (MAD) study of PRX002/RG7935 and thirty-five age-and gender-matched healthy individuals (i.e. healthy controls - HC) in a separate study performed smartphone-based assessments for up to 24weeks and up to 6 weeks, respectively. The assessments included "active gait tests", where all participants were asked to walk for 30 s with at least one 180. turn, and "passive monitoring", in which subjects carried the smartphone in a pocket or fanny pack as part of their daily routine. In total, over 6,600 active gait tests and over 30,000 h of passive monitoring data were collected. A mobility analysis indicates that patients with PD are less mobile than HCs, as manifested in time spent in gait-related activities, number of turns and sit-to-stand transitions, and power per step. It supports the potential use of smartphones for continuous mobility monitoring in future clinical practice and drug development.
Year
DOI
Venue
2017
10.1007/978-3-319-98551-0_2
Lecture Notes of the Institute for Computer Sciences, Social Informatics, and Telecommunications Engineering
Keywords
Field
DocType
Sensors,Activity recognition,Smartphone,Accelerometer,Machine learning,Deep learning,Parkinson's disease,Clinical trial
Parkinson's disease,Passive monitoring,Gait,Accelerometer,Clinical Practice,Clinical trial,Mobility analysis,Physical medicine and rehabilitation,Medicine
Conference
Volume
ISSN
Citations 
247
1867-8211
0
PageRank 
References 
Authors
0.34
5
25