Title
Mathematical Modeling of HPA axis Using Particle Filter Algorithm
Abstract
This article studies incremental prediction in the context of of a previously contributed model of the Hypothalamus-Pituitary-Adrenal gland (HPA) axis based on the particle filter algorithm. The model considers individual-level circadian rhythm in the context of three coupled nonlinear differential equations of the HPA axis, including Corticotropin-Releasing hormone (CRH), Adrenocorticotropic hormone (ACTH), and Cortisol as state variables. A particle filter approach is proposed to estimate and sample from model state in the context of incoming data in the context of non-linearity, non-Gaussian behavior, as well as stochastic parameters and process noise. The simulation results suggests a high potential for use of particle filtering in prediction of HPA axis state in the context of periodically incoming data.
Year
DOI
Venue
2018
10.1109/ICHI.2018.00073
2018 IEEE International Conference on Healthcare Informatics (ICHI)
Keywords
Field
DocType
HPA axis,Particle Filter,Modeling
Data modeling,Adrenocorticotropic hormone,Computer science,Particle filter,Algorithm,Process noise,Nonlinear differential equations,Context model,State variable,Particle filtering algorithm
Conference
ISBN
Citations 
PageRank 
978-1-5386-5378-4
0
0.34
References 
Authors
0
3
Name
Order
Citations
PageRank
Amin Mohammadbagheri100.34
Connie Lillas200.34
Nathaniel D. Osgood3239.92