Paper Info
Title
A miniaturized brain-machine-spinal cord interface (BMSI) for closed-loop intraspinal microstimulation.
Abstract
This paper reports on a fully miniaturized brain-machine-spinal cord interface (BMSI) for closed-loop cortical control of intraspinal microstimulation (ISMS). The system incorporates two identical 4-channel modules, with each module comprising a neural recording front-end, embedded digital signal processing (DSP) unit, and programmable stimulating back-end. The DSP unit is capable of generating multichannel trigger signals for a wide array of ISMS triggering patterns based upon online discrimination of a programmable number of intracortical neural spikes within a pre-specified time bin via thresholding and time-amplitude windowing. The BMSI system is validated experimentally in a rat model of contusion spinal cord injury (SCI) by converting in real-time multichannel neural spikes recorded from the cerebral cortex into electrical stimuli delivered to the lumbar spinal cord below the level of the injury, resulting in distinct patterns of hindlimb muscle activation in the SCI rat.
Year
Venue
Keywords
2016
PROCEEDINGS OF 2016 IEEE BIOMEDICAL CIRCUITS AND SYSTEMS CONFERENCE (BIOCAS)
Brain-machine-spinal cord interface,closed-loop neuromodulation,intraspinal microstimulation,neural recording,spike discrimination,spinal cord injury,system-on-chip
Field
DocType
ISSN
Spinal cord,Spinal cord injury,Digital signal processing,Neuroscience,Microstimulation,Computer science,Muscle activation,Lumbar Spinal Cord,Cerebral cortex,Cord
Conference
2163-4025
Citations 
PageRank 
References 
0
0.34
0
Authors
8
Name
Order
Citations
PageRank
Shahab Shahdoost162.06
Shawn Frost241.29
David J Guggenmos3647.07
Jordan Borrell400.34
Caleb Dunham541.29
Scott Barbay6687.69
Randolph J Nudo7687.69
Pedram Mohseni819748.29