Title | ||
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Assessment of Spatial Heterogeneity of Ventricular Repolarization after Quinidine in Healthy Subjects. |
Abstract | ||
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When spatial heterogeneity of ventricular repolarization (SHVR) increases, vulnerability to ventricular arrhythmias, including lethal ones, has also been observed to increase. Drug-induced multi-ion-channel blocks may increase SHVR. Aim of this study is to non-invasively assess whether quinidine, a strong hERG potassium channel blocker with weaker effects on calcium and late sodium currents, increases SHVR. We analyzed data from 21 healthy subjects that received both the drug and a placebo and underwent to 12 leads Holter monitoring. From the recording, three 10-s ECGs were extracted at each of 16 predefined time-points. SHVR was assessed by the V-index, which evaluates the standard deviation of the repolarization times from multi-lead ECG recordings. At any time point, a value of V-index was computed for each of the three 10s ECGs and averaged if the difference in the mean RR of the 10s ECGs was lower than 50 ms. The V-index did not change after the placebo (V-index pre-dose = 29.2 ± 9.9 ms vs. V-indexpost-dose1h = 26.7 ± 10.3, ns), whereas, after quinidine, it significantly increased one hour post-dose (V-index pre-dose = 29.5 ± 10.2 ms vs. V-indexpost-dose1h = 46.5 ± 33.8 ms, p = 0.01). Quinidine had its maximum effect on the V-index 2.5 h after dose (V-index post-dose2.5h =53.6 ± 39.6 ms). |
Year | Venue | Field |
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2017 | CinC | hERG,Calcium,Internal medicine,Cardiology,Quinidine,Potassium channel blocker,Repolarization,Medicine,Ventricular Repolarization,Placebo |
DocType | Citations | PageRank |
Conference | 0 | 0.34 |
References | Authors | |
0 | 4 |
Name | Order | Citations | PageRank |
---|---|---|---|
Valentina D. A. Corino | 1 | 30 | 12.91 |
Roberto Sassi | 2 | 139 | 19.26 |
Luca T. Mainardi | 3 | 106 | 26.02 |
Massimo W Rivolta | 4 | 0 | 4.73 |