Paper Info
Title
Assessing Detection Limits in Magnetic Nanoparticle Enhanced Microwave Imaging.
Abstract
Magnetic nanoparticles-aided microwave imaging is an emerging modality for the diagnosis of early stage tumors. It exploits the possibility of modulating the response at microwaves of magnetic nanoparticles, employed as contrast agent selectively accumulated into the tumor. In this paper, we describe the results of an experimental study aimed at establishing the actual detection limits of the approach, namely the minimum amount of magnetic nanoparticles to be delivered for a reliable imaging. The assessment is carried out on breast phantoms made of ex-vivo minced pig tissues and using commercially available magnetic nanoparticles. The results show that it is possible to detect amounts of magnetic nanoparticles between 2 and 7 mg, dispersed in a volume of about one cubic centimeter, depending on the breast type. While such quantities are already consistent with those currently reachable via active selective targeting, an in-depth analysis of the results allows to identify strategies to further lower the detection limits up to four times, by refining the measurement set-up and setting the amplitude of the polarizing magnetic field modulating the nanoparticle response to a suitable value.
Year
DOI
Venue
2018
10.1109/ACCESS.2018.2861461
IEEE ACCESS
Keywords
Field
DocType
Microwave imaging,cancer detection,medical diagnostic imaging,nanoparticles,contrast enhanced microwave imaging,magnetic nanoparticles
Microwave,Magnetic field,Computer science,Modulation,Microwave imaging,Cubic centimetre,Magnetic nanoparticles,Optoelectronics,Amplitude,Nanoparticle,Distributed computing
Journal
Volume
ISSN
Citations 
6
2169-3536
0
PageRank 
References 
Authors
0.34
0
6
Name
Order
Citations
PageRank
Ovidio M Bucci1182.71
Gennaro Bellizzi2326.48
Sandra Costanzo32511.48
Lorenzo Crocco49715.77
Giuseppe Di Massa5155.72
Rosa Scapaticci6273.96