Paper Info
Title
On the importance of precise electrode placement for targeted transcranial electric stimulation.
Abstract
Transcranial electric stimulation (TES) is an increasingly popular method for non-invasive modulation of brain activity and a potential treatment for neuropsychiatric disorders. However, there are concerns about the reliability of its application because of variability in TES-induced intracranial electric fields across individuals. While realistic computational models offer can help to alleviate these concerns, their direct empirical validation is sparse, and their practical implications are not always clear. In this study, we combine direct intracranial measurements of electric fields generated by TES in surgical epilepsy patients with computational modeling. First, we directly validate the computational models and identify key parameters needed for accurate model predictions. Second, we derive practical guidelines for a reliable application of TES in terms of the precision of electrode placement needed to achieve a desired electric field distribution. Based on our results, we recommend electrode placement accuracy to be < 1 cm for a reliable application of TES across sessions.
Year
DOI
Venue
2018
10.1016/j.neuroimage.2018.07.027
NeuroImage
Field
DocType
Volume
Psychology,Cognitive psychology,Electronic engineering,Brain activity and meditation,Computational model
Journal
181
ISSN
Citations 
PageRank 
1053-8119
0
0.34
References 
Authors
7
6
Name
Order
Citations
PageRank
Alexander Opitz1666.97
Erin Yeagle200.34
Axel Thielscher314826.20
Charles E. Schroeder45810.07
Ashesh D. Mehta5685.31
Michael P. Milham6614.45