Paper Info
Title
Stability and reproducibility of co-electrospun brain-mimicking phantoms for quality assurance of diffusion MRI sequences.
Abstract
Grey and white matter mimicking phantoms are important for assessing variations in diffusion MR measures at a single time point and over an extended period of time. This work investigates the stability of brain-mimicking microfibre phantoms and reproducibility of their MR derived diffusion parameters. The microfibres were produced by co-electrospinning and characterized by scanning electron microscopy (SEM). Grey matter and white matter phantoms were constructed from random and aligned microfibres, respectively. MR data were acquired from these phantoms over a period of 33 months. SEM images revealed that only small changes in fibre microstructure occurred over 30 months. The coefficient of variation in MR measurements across all time-points was between 1.6% and 3.4% for MD across all phantoms and FA in white matter phantoms. This was within the limits expected for intra-scanner variability, thereby confirming phantom stability over 33 months. These specialised diffusion phantoms may be used in a clinical environment for intra and inter-site quality assurance purposes, and for validation of quantitative diffusion biomarkers.
Year
DOI
Venue
2018
10.1016/j.neuroimage.2018.06.059
NeuroImage
Keywords
Field
DocType
Diffusion MRI,Brain phantom,Hollow microfibres,Co-electrospinning,White matter phantom,Grey matter phantom
Biomedical engineering,Reproducibility,Diffusion MRI,Grey matter,White matter,Imaging phantom,Psychology,Cognitive psychology,Quality assurance
Journal
Volume
ISSN
Citations 
181
1053-8119
0
PageRank 
References 
Authors
0.34
3
5
Name
Order
Citations
PageRank
Matthew Grech-Sollars100.34
Feng-Lei Zhou231.55
Adam Waldman371.17
Geoffrey J. M. Parker444439.62
Penny L. Hubbard Cristinacce500.34