Name
Abstract | ||
|---|---|---|
Comparative studies of protein sequences are widely used in evolutionary and comparative genomics studies, but there is a lack of efficient tools to identify conserved regions ab initio within a protein multiple alignment. PROBE provides a fully automatic analysis of protein family conservation, to identify conserved regions, or 'blocks', that may correspond to structural/functional domains or motifs. Conserved blocks are identified at two different levels: (i) family level blocks indicate sites that are probably of central importance to the protein's structure or function, and (ii) sub-family level blocks highlight regions that may signify functional specialization, such as binding partners, etc. All conserved blocks are mapped onto a phylogenetic tree and can also be visualized in the context of the multiple sequence alignment. PROBE thus facilitates in-depth studies of sequence-structure-function-evolution relationships, and opens the way to block-level phylogenetic profiling. Availability and implementation: Freely available on the web at http://www.lbgi.fr/similar to julie/probe/web. |
Year | DOI | Venue |
|---|---|---|
2018 | 10.1093/bioinformatics/bty367 | BIOINFORMATICS |
Field | DocType | Volume |
Data mining,Visualization,Computer science | Journal | 34 |
Issue | ISSN | Citations |
19 | 1367-4803 | 1 |
PageRank | References | Authors |
0.38 | 5 | 4 |
Name | Order | Citations | PageRank |
|---|---|---|---|
| Arnaud Kress | 1 | 5 | 2.22 |
| Odile Lecompte | 2 | 63 | 5.97 |
| O Poch | 3 | 716 | 70.43 |
| Julie D. Thompson | 4 | 2 | 1.42 |