Title
An Integrative Framework For The Construction Of Big Functional Networks
Abstract
We present a methodology for biological data integration, aiming at building and analysing large functional networks which model complex genotype-phenotype associations. A functional network is a graph where nodes represent cellular components (e.g., genes, proteins, mRNA, etc.) and edges represent associations among such molecules. Different types of components may cohesist in the same network, and associations may be related to physical/biochemical interactions or functional/phenotipic relationships. Due to both the large amount of involved information and the computational complexity typical of the problems in this domain, the proposed framework is based on big data technologies (Spark and NoSQL databases).
Year
DOI
Venue
2018
10.1109/BIBM.2018.8621128
PROCEEDINGS 2018 IEEE INTERNATIONAL CONFERENCE ON BIOINFORMATICS AND BIOMEDICINE (BIBM)
Keywords
Field
DocType
Integrative approaches, biological networks, big data technologies
Graph,Biological data,Spark (mathematics),Computer science,Biological network,Functional networks,Theoretical computer science,NoSQL,Artificial intelligence,Big data,Machine learning,Computational complexity theory
Conference
ISSN
Citations 
PageRank 
2156-1125
0
0.34
References 
Authors
0
3
Name
Order
Citations
PageRank
Claudia Giallombardo101.01
Salvatore Morfea200.34
Simona E. Rombo319222.21