Name
Abstract | ||
|---|---|---|
In the area of biomedical engineering, digital-microfluidic biochips (DMFBs) have received considerable attention because of their capability of providing an efficient and reliable platform for conducting point-of-care clinical diagnostics. System reliability, in turn, mandates error-recoverability while implementing biochemical assays on-chip for medical applications. Unfortunately, the technology of DMFBs is not yet fully equipped to handle error-recovery from various microfluidic operations involving droplet motion and reaction. Recently, a number of cyber-physical systems have been proposed to provide real-time checking and error-recovery in assays based on the feedback received from a few on-chip checkpoints. However, to synthesize robust feedback systems for different types of DMFBs, certain practical issues need to be considered such as co-optimization of checkpoint placement, error-recoverability, and layout of droplet-routing pathways. For application-specific DMFBs, we propose here an algorithm that minimizes the number of checkpoints and determines their locations to cover every path in a given droplet-routing solution. Next, for general-purpose DMFBs, where the checkpoints are pre-deployed in specific locations, we present a checkpoint-aware routing algorithm such that every droplet-routing path passes through at least one checkpoint to enable error-recovery and to ensure physical routability of all droplets. Furthermore, we also propose strategies for executing the algorithms in reliable mode to enhance error-recoverability. The proposed methods thus provide reliability-hardening mechanisms for a wide class of cyber-physical DMFBs.
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Year | DOI | Venue |
|---|---|---|
2018 | 10.1145/3229052 | JETC |
Keywords | DocType | Volume |
Physical design automation, biochips, checkpoint, droplet routing, microfluidics, sensor | Journal | 14 |
Issue | ISSN | Citations |
3 | 1550-4832 | 0 |
PageRank | References | Authors |
0.34 | 20 | 5 |
Name | Order | Citations | PageRank |
|---|---|---|---|
| Guan-Ruei Lu | 1 | 0 | 0.34 |
| Ansuman Banerjee | 2 | 170 | 41.69 |
| Bhargab B. Bhattacharya | 3 | 848 | 118.02 |
| Tsung-Yi Ho | 4 | 59 | 21.63 |
| Hung-Ming Chen | 5 | 493 | 59.19 |