Paper Info
Title
Influence Of Cholecystokinin-8 On Compound Nerve Action Potentials From Ventral Gastric Vagus In Rats
Abstract
Objective: Vagus Nerve Stimulation (VNS) has shown great promise as a potential therapy for a number of conditions, such as epilepsy, depression and for Neurometabolic Therapies, especially for treating obesity. The objective of this study was to characterize the left ventral subdiaphragmatic gastric trunk of vagus nerve (SubDiaGVN) and to analyze the influence of intravenous injection of gut hormone cholecystokinin octapeptide (CCK-8) on compound nerve action potential (CNAP) observed on the same branch, with the aim of understanding the impact of hormones on VNS and incorporating the methods and results into closed loop implant design. Methods: The cervical region of the left vagus nerve (CerVN) of male Wistar rats was stimulated with electric current and the elicited CNAPs were recorded on the SubDiaGVN under four different conditions: Control (no injection), Saline, CCK1 (100 pmol/kg) and CCK2 (1000 pmol/kg) injections. Results: We identified the presence of A delta, B, C1, C2, C3 and C4 fibers with their respective velocity ranges. Intravenous administration of CCK in vivo results in selective, statistically significant reduction of CNAP components originating from A and B fibers, but with no discernible effect on the C fibers in n = 7 animals. The affected CNAP components exhibit statistically significant (p(Saline-CCK1) = 0.02 and p(Saline-CCK2) = 0.007) higher normalized stimulation thresholds. Conclusion: This approach of characterizing the vagus nerve can be used in closed loop systems to determine when to initiate VNS and also to tune the stimulation dose, which is patientspecific and changes over time.
Year
DOI
Venue
2018
10.1142/S0129065718500065
INTERNATIONAL JOURNAL OF NEURAL SYSTEMS
Keywords
Field
DocType
Compound nerve action potentials, subdiaphragmatic vagus nerve, vagus nerve stimulation, closed loop system
Stomach,Vagus nerve stimulation,Neuroscience,Pattern recognition,Computer science,Vagus nerve,Epilepsy,Artificial intelligence,Sincalide,Cholecystokinin
Journal
Volume
Issue
ISSN
28
9
0129-0657
Citations 
PageRank 
References 
0
0.34
2
Authors
7
Name
Order
Citations
PageRank
Khalid B. Mirza102.70
Andrea Alenda200.34
Amir Eftekhar3194.19
Nir Grossman400.34
Konstantin Nikolic5268.09
Stephen R. Bloom601.01
Christofer Toumazou726559.06