Name
Title | ||
|---|---|---|
Chronic obstructive pulmonary disease phenotypes using cluster analysis of electronic medical records. |
Abstract | ||
|---|---|---|
Chronic obstructive pulmonary disease is a heterogeneous disease. In this retrospective study, we hypothesize that it is possible to identify clinically relevant phenotypes by applying clustering methods to electronic medical records. We included all the patients >40 years with a diagnosis of chronic obstructive pulmonary disease admitted to the University of New Mexico Hospital between 1 January 2011 and 1 May 2014. We collected admissions, demographics, comorbidities, severity markers and treatments. A total of 3144 patients met the inclusion criteria: 46 percent were >65 years and 52 percent were males. The median Charlson score was 2 (interquartile range: 1-4) and the most frequent comorbidities were depression (36%), congestive heart failure (25%), obesity (19%), cancer (19%) and mild liver disease (18%). Using the sphere exclusion method, nine clusters were obtained: depression-chronic obstructive pulmonary disease, coronary artery disease-chronic obstructive pulmonary disease, cerebrovascular disease-chronic obstructive pulmonary disease, malignancy-chronic obstructive pulmonary disease, advanced malignancy-chronic obstructive pulmonary disease, diabetes mellitus-chronic kidney disease-chronic obstructive pulmonary disease, young age-few comorbidities-high readmission rates-chronic obstructive pulmonary disease, atopy-chronic obstructive pulmonary disease, and advanced disease-chronic obstructive pulmonary disease. These clusters will need to be validated prospectively. |
Year | DOI | Venue |
|---|---|---|
2018 | 10.1177/1460458216675661 | HEALTH INFORMATICS JOURNAL |
Keywords | Field | DocType |
asthma,comorbidity,chronic obstructive pulmonary disease,epidemiology,factor analysis,phenotype | Disease,Nursing,Asthma,Epidemiology,Intensive care medicine,Comorbidity,Medical record,Retrospective cohort study,Medical emergency,Medicine | Journal |
Volume | Issue | ISSN |
24.0 | SP4.0 | 1460-4582 |
Citations | PageRank | References |
0 | 0.34 | 2 |
Authors | ||
5 | ||
Name | Order | Citations | PageRank |
|---|---|---|---|
| Rodrigo Vazquez Guillamet | 1 | 0 | 0.34 |
| Oleg Ursu | 2 | 7 | 2.88 |
| Gary Iwamoto | 3 | 0 | 0.34 |
| Pope L. Moseley | 4 | 0 | 0.34 |
| Tudor I Oprea | 5 | 359 | 46.89 |