Name
Abstract | ||
|---|---|---|
The planarian Schmidtea mediterranea is an important model for stem cell research and regeneration, but adequate genome resources for this species have been lacking. Here we report a highly contiguous genome assembly of S. mediterranea, using long-read sequencing and a de novo assembler (MARVEL) enhanced for low-complexity reads. The S. mediterranea genome is highly polymorphic and repetitive, and harbours a novel class of giant retroelements. Furthermore, the genome assembly lacks a number of highly conserved genes, including critical components of the mitotic spindle assembly checkpoint, but planarians maintain checkpoint function. Our genome assembly provides a key model system resource that will be useful for studying regeneration and the evolutionary plasticity of core cell biological mechanisms. |
Year | DOI | Venue |
|---|---|---|
2018 | 10.1038/nature25473 | NATURE |
DocType | Volume | Issue |
Journal | 554 | 7690 |
ISSN | Citations | PageRank |
0028-0836 | 1 | 0.39 |
References | Authors | |
1 | 13 | |
Name | Order | Citations | PageRank |
|---|---|---|---|
| Markus Alexander Grohme | 1 | 1 | 0.39 |
| Siegfried Schloissnig | 2 | 1 | 0.39 |
| Andrei Rozanski | 3 | 1 | 0.39 |
| Martin Pippel | 4 | 1 | 0.39 |
| George Robert Young | 5 | 1 | 0.39 |
| Sylke Winkler | 6 | 1 | 0.39 |
| Holger Brandl | 7 | 6 | 1.47 |
| Ian Henry | 8 | 6 | 1.47 |
| Andreas Dahl | 9 | 1 | 0.39 |
| Sean Powell | 10 | 1 | 0.39 |
| Michael Hiller | 11 | 38 | 4.98 |
| Eugene Myers | 12 | 3164 | 496.92 |
| Jochen C. Rink | 13 | 6 | 1.81 |