Name
Title | ||
|---|---|---|
ComplexContact: a web server for inter-protein contact prediction using deep learning. |
Abstract | ||
|---|---|---|
ComplexContact (http://raptorx2.uchicago.edu/ComplexContact/) is a web server for sequencebased interfacial residue-residue contact prediction of a putative protein complex. Interfacial residue-residue contacts are critical for understanding how proteins form complex and interact at residue level. When receiving a pair of protein sequences, ComplexContact first searches for their sequence homologs and builds two paired multiple sequence alignments (MSA), then it applies co-evolution analysis and a CASP-winning deep learning (DL) method to predict interfacial contacts from paired MSAs and visualizes the prediction as an image. The DL method was originally developed for intra-protein contact prediction and performed the best in CASP12. Our large-scale experimental test further shows that ComplexContact greatly outperforms pure co-evolution methods for inter-protein contact prediction, regardless of the species. |
Year | DOI | Venue |
|---|---|---|
2018 | 10.1093/nar/gky420 | NUCLEIC ACIDS RESEARCH |
Field | DocType | Volume |
Genome,World Wide Web,Biology,Artificial intelligence,Deep learning,Genetics,Web server | Journal | 46 |
Issue | ISSN | Citations |
W1 | 0305-1048 | 1 |
PageRank | References | Authors |
0.35 | 14 | 7 |
Name | Order | Citations | PageRank |
|---|---|---|---|
| Hong Zeng | 1 | 7 | 3.85 |
| Sheng Wang | 2 | 265 | 28.52 |
| Tianming Zhou | 3 | 1 | 0.35 |
| Feifeng Zhao | 4 | 1 | 0.35 |
| Li, Xiufeng | 5 | 1 | 0.68 |
| Qing Wu | 6 | 374 | 34.70 |
| Xu, Jinbo | 7 | 888 | 66.00 |