Title
EviNet: a web platform for network enrichment analysis with flexible definition of gene sets.
Abstract
The new web resource EviNet provides an easily run interface to network enrichment analysis for exploration of novel, experimentally defined gene sets. The major advantages of this analysis are (i) applicability to any genes found in the global network rather than only to those with pathway/ontology term annotations, (ii) ability to connect genes via different molecular mechanisms rather than within one highthroughput platform, and (iii) statistical power sufficient to detect enrichment of very small sets, down to individual genes. The users' gene sets are either defined prior to upload or derived interactively from an uploaded file by differential expression criteria. The pathways and networks used in the analysis can be chosen from the collection menu. The calculation is typically done within seconds or minutes and the stable URL is provided immediately. The results are presented in both visual (network graphs) and tabular formats using jQuery libraries. Uploaded data and analysis results are kept in separated project directories not accessible by other users. EviNet is available at https://www.evinet.org/.
Year
DOI
Venue
2018
10.1093/nar/gky485
NUCLEIC ACIDS RESEARCH
Field
DocType
Volume
Gene,Biology,Computational biology,Genetics
Journal
46
Issue
ISSN
Citations 
W1
0305-1048
0
PageRank 
References 
Authors
0.34
24
6
Name
Order
Citations
PageRank
Ashwini Jeggari1161.80
Zhanna Alekseenko200.34
Iurii Petrov300.68
José M Dias400.34
Johan Ericson500.34
Andrey Alexeyenko6101.55