Paper Info
Title
Exploring the functional impact of alternative splicing on human protein isoforms using available annotation sources.
Abstract
In recent years, the emphasis of scientific inquiry has shifted from whole-genome analyses to an understanding of cellular responses specific to tissue, developmental stage or environmental conditions. One of the central mechanisms underlying the diversity and adaptability of the contextual responses is alternative splicing (AS). It enables a single gene to encode multiple isoforms with distinct biological functions. However, to date, the functions of the vast majority of differentially spliced protein isoforms are not known. Integration of genomic, proteomic, functional, phenotypic and contextual information is essential for supporting isoform-based modeling and analysis. Such integrative proteogenomics approaches promise to provide insights into the functions of the alternatively spliced protein isoforms and provide high-confidence hypotheses to be validated experimentally. This manuscript provides a survey of the public databases supporting isoform-based biology. It also presents an overview of the potential global impact of AS on the human canonical gene functions, molecular interactions and cellular pathways.
Year
DOI
Venue
2019
10.1093/bib/bby047
BRIEFINGS IN BIOINFORMATICS
Keywords
Field
DocType
alternative splicing,isoform,protein function,pathway,interaction,context-specific
Gene isoform,Annotation,Biology,Alternative splicing,Bioinformatics,Computational biology
Journal
Volume
Issue
ISSN
20
5
1467-5463
Citations 
PageRank 
References 
0
0.34
6
Authors
10
Name
Order
Citations
PageRank
Dinanath Sulakhe118318.55
Mark D'souza215026.50
Sheng Wang326528.52
Sandhya Balasubramanian4101.91
Prashanth Athri5181.41
Bingqing Xie6233.23
Stefan Canzar711614.05
Gady Agam839143.99
T Conrad Gilliam900.34
N Maltsev1023958.35