Paper Info
Title
MoonDB 2.0: an updated database of extreme multifunctional and moonlighting proteins.
Abstract
MoonDB 2.0 (http://moondb.hb.univ-amu.fr/) is a database of predicted and manually curated extreme multifunctional (EMF) and moonlighting proteins, i.e. proteins that perform multiple unrelated functions. We have previously shown that such proteins can be predicted through the analysis of their molecular interaction subnetworks, their functional annotations and their association to distinct groups of proteins that are involved in unrelated functions. In MoonDB 2.0, we updated the set of human EMF proteins (238 proteins), using the latest functional annotations and protein-protein interaction networks. Furthermore, for the first time, we applied our method to four additional model organisms - mouse, fly, worm and yeast - and identified 54 novel EMF proteins in these species. In addition to novel predictions, this update contains 63 human and yeast proteins that were manually curated from literature, including descriptions of moonlighting functions and associated references. Importantly, MoonDB's interface was fully redesigned and improved, and its entries are now cross-referenced in the UniProt Knowledgebase (UniProtKB). MoonDB will be updated once a year with the novel EMF candidates calculated from the latest available protein interactions and functional annotations.
Year
DOI
Venue
2019
10.1093/nar/gky1039
NUCLEIC ACIDS RESEARCH
Field
DocType
Volume
Protein–protein interaction,UniProt Knowledgebase,Biology,UniProt,Binding (Molecular Function),Yeast Proteins,Genetics,Database,Protein moonlighting
Journal
47
Issue
ISSN
Citations 
D1
0305-1048
0
PageRank 
References 
Authors
0.34
7
5
Name
Order
Citations
PageRank
Diogo M Ribeiro100.34
Galadriel Briere200.34
Benoit Bely3515.25
Lionel Spinelli400.68
Christine Brun516911.90