Name
Abstract | ||
|---|---|---|
Background: Recent studies have shown that subclinical valve thrombosis in heart valve prosthesis (HVP) can be responsible for reduced leaflet motion detectable only by advanced imaging diagnostics. We conceived a novel sensorized HVP able to detect earlier any thrombus formation that may alter the leaflets motion using an electric impedance measurement, IntraValvular Impedance (IVI). Methods: For IVI measurement, dedicated electrodes are embedded in the structure of the HVP to generate a local electric field that is altered by the moving valve leaflets during their cyclic opening/closing. We present preliminary in vitro results using a first prototype of sensorized mechanical heart valve connected to an external impedance measurement system. The prototype was tested on a circulatory mock loop system and the IVI signals were recorded during both normal dynamics and experimentally induced altered working of the leaflets. Results: Recordings showed a very repetitive and stable IVI signal during the normal cyclic opening/closing of the HVP. The induced alterations in leaflet motion were reflected in the IVI signal. Conclusions: The novel sensorized HVP has great potential to give early warning of possible subclinical valve thrombosis altering the valve leaflet motion, and to help in tailoring the anticoagulation therapy. |
Year | DOI | Venue |
|---|---|---|
2018 | 10.3390/s18113905 | SENSORS |
Keywords | Field | DocType |
heart valve prosthesis,valve thrombosis,electric impedance,implantable sensor,continuous monitoring | Biomedical engineering,Prosthesis,Heart valve,Electronic engineering,Engineering | Journal |
Volume | Issue | ISSN |
18 | 11.0 | 1424-8220 |
Citations | PageRank | References |
1 | 0.43 | 0 |
Authors | ||
4 | ||
Name | Order | Citations | PageRank |
|---|---|---|---|
| Emanuela Marcelli | 1 | 2 | 1.88 |
| Barbara Bortolani | 2 | 1 | 0.77 |
| Ivan Corazza | 3 | 5 | 4.29 |
| Laura Cercenelli | 4 | 3 | 2.24 |