Paper Info
Title
SCOPe: classification of large macromolecular structures in the structural classification of proteins-extended database.
Abstract
The SCOPe (Structural Classification of Proteinsextended, https://scop.berkeley.edu) database hierarchically classifies domains from the majority of proteins of known structure according to their structural and evolutionary relationships. SCOPe also incorporates and updates the ASTRAL compendium, which provides multiple databases and tools to aid in the analysis of the sequences and structures of proteins classified in SCOPe. Protein structures are classified using a combination of manual curation and highly precise automated methods. In the current release of SCOPe, 2.07, we have focused our manual curation efforts on larger protein structures, including the spliceosome, proteasome and RNA polymerase I, as well as many other Pfam families that had not previously been classified. Domains from these large protein complexes are distinctive in several ways: novel non-globular folds are more common, and domains from previously observed protein families often have N- or C-terminal extensions that were disordered or not present in previous structures. The current monthly release update, SCOPe 2.07-2018-10-18, classifies 90 992 PDB entries (about two thirds of PDB entries).
Year
DOI
Venue
2019
10.1093/nar/gky1134
NUCLEIC ACIDS RESEARCH
Field
DocType
Volume
Protein family,Multicatalytic endopeptidase complex,Compendium,Biology,Structural classification,Spliceosome,Structural Classification of Proteins database,Protein Data Bank (RCSB PDB),Database,Protein structure
Journal
47
Issue
ISSN
Citations 
D1
0305-1048
3
PageRank 
References 
Authors
0.39
14
3
Name
Order
Citations
PageRank
John-Marc Chandonia158356.85
Naomi K. Fox2762.93
Steven E Brenner31679308.17