Title
Oscillations-free PID control of anesthetic drug delivery in neuromuscular blockade.
Abstract
•Oscillations-free closed-loop PID controlled drug delivery in neuromuscular blockade is considered.•Bifurcation analysis shows that oscillations can be avoided by properly adjusting the overall gain of the PID controller.•The time-varying gain neither affects the stability of the control system nor causes new nonlinear dynamical phenomena.•Two particle filters and Extended Kalman Filter are compared performance-wise on synthetic and real data from surgery room.•The particle filters perform better in terms of bias in the phases of surgery where the system output significantly varies.
Year
DOI
Venue
2019
10.1016/j.cmpb.2016.07.025
Computer Methods and Programs in Biomedicine
Keywords
Field
DocType
Closed-loop drug delivery,Nonlinear systems,Oscillations,Parameter estimation,Particle,Filters Wiener models
Neuromuscular Blockade,Extended Kalman filter,Control theory,Nonlinear system,PID controller,Control theory,Computer science,Control system,Estimation theory,Linearization
Journal
Volume
ISSN
Citations 
171
0169-2607
0
PageRank 
References 
Authors
0.34
0
4
Name
Order
Citations
PageRank
Alexander Medvedev17222.43
Zhanybai T. Zhusubaliyev28229.09
Olov Rosen3234.10
Margarida Martins da Silva4124.56