Title
Reframing gene essentiality in terms of adaptive flexibility.
Abstract
Longer-term growth experiments followed by whole genome sequencing and transcriptome analysis can provide a better understanding of conditional gene essentiality and mechanisms of adaptation to such perturbations. Compensatory mutations are largely reproducible mechanisms and are in agreement with genome-scale modeling predictions to loss of function gene deletion events.
Year
DOI
Venue
2018
10.1186/s12918-018-0653-z
BMC Systems Biology
Keywords
Field
DocType
Adaptive evolution,Essentiality,Genome-scale model
Cognitive reframing,Gene,Biology,Gene knockout,Systems biology,Cell biology,Computational biology,Computational analysis,Isozyme
Journal
Volume
Issue
ISSN
12
1
1752-0509
Citations 
PageRank 
References 
0
0.34
7
Authors
9