Title
Evaluating the Impact of Intensity Normalization on MR Image Synthesis.
Abstract
Image synthesis learns a transformation from the intensity features of an input image to yield a different tissue contrast of the output image. This process has been shown to have application in many medical image analysis tasks including imputation, registration, and segmentation. To carry out synthesis, the intensities of the input images are typically scaled-i.e., normalized-both in training to learn the transformation and in testing when applying the transformation, but it is not presently known what type of input scaling is optimal. In this paper, we consider seven different intensity normalization algorithms and three different synthesis methods to evaluate the impact of normalization. Our experiments demonstrate that intensity normalization as a preprocessing step improves the synthesis results across all investigated synthesis algorithms. Furthermore, we show evidence that suggests intensity normalization is vital for successful deep learning-based MR image synthesis.
Year
DOI
Venue
2019
10.1117/12.2513089
Proceedings of SPIE
Keywords
DocType
Volume
intensity normalization,image synthesis,brain MRI
Conference
10949
ISSN
Citations 
PageRank 
0277-786X
1
0.36
References 
Authors
0
4
Name
Order
Citations
PageRank
Jacob C. Reinhold111.04
Blake Dewey2114.24
Aaron Carass338343.15
Jerry L. Prince44990488.42