Title
Disease Detection in Weakly Annotated Volumetric Medical Images using a Convolutional LSTM Network.
Abstract
We explore a solution for learning disease signatures from weakly, yet easily obtainable, annotated volumetric medical imaging data by analyzing 3D volumes as a sequence of 2D images. We demonstrate the performance of our solution in the detection of emphysema in lung cancer screening low-dose CT images. Our approach utilizes convolutional long short-term memory (LSTM) to scan sequentially through an imaging volume for the presence of disease in a portion of scanned region. This framework allowed effective learning given only volumetric images and binary disease labels, thus enabling training from a large dataset of 6,631 un-annotated image volumes from 4,486 patients. When evaluated in a testing set of 2,163 volumes from 2,163 patients, our model distinguished emphysema with area under the receiver operating characteristic curve (AUC) of .83. This approach was found to outperform 2D convolutional neural networks (CNN) implemented with various multiple-instance learning schemes (AUC=0.69-0.76) and a 3D CNN (AUC=.77).
Year
Venue
DocType
2018
arXiv: Computer Vision and Pattern Recognition
Journal
Volume
Citations 
PageRank 
abs/1812.01087
0
0.34
References 
Authors
0
3
Name
Order
Citations
PageRank
Nathaniel Braman100.34
David Beymer200.68
Ehsan Dehghan300.34