Paper Info
Title
Modeling Nitric Oxide Induced Neural Activity and Neurovascular Coupling in a Cerebellum Circuit
Abstract
Functional magnetic resonance imaging (fMRI) allows to identify brain regions activated during rest, normal and diseased conditions attributing a function or a task to microcircuit activity. In order to understand signals from fMRI techniques, bottom-up modeling would be needed to reconstruct the neurovascular coupling attributing neural activity to local blood flow changes. In this paper, we present a bottom-up mathematical modeling of neuro-vascular coupling in rat cerebellum granule cells. Granule cells are numerous and main source for NO production in cerebellum. While matching experimental estimations, the effect of cerebellar blood flow and neural activity, a model of nitric oxide (NO) in the cerebellar granular was simulated and the diffusion, production and consumption of NO at the synapse and the contribution for neuro vascular coupling was modeled. This paper showcases the first step attributing cerebellum sub-molecular changes to clinical observations reconstructing neural activity mappings to population responses when combined with BOLD modeling.
Year
DOI
Venue
2018
10.1109/ICACCI.2018.8554776
2018 International Conference on Advances in Computing, Communications and Informatics (ICACCI)
Keywords
Field
DocType
computational neuroscience,neural activity,cerebellum,granule cell,neurovascular coupling
Population,Synapse,Neuroscience,Functional magnetic resonance imaging,Blood flow,Computer science,Control theory,Neurovascular bundle,Artificial neural network,Nitric oxide,Cerebellum
Conference
ISBN
Citations 
PageRank 
978-1-5386-5315-9
0
0.34
References 
Authors
2
4
Name
Order
Citations
PageRank
Sreedev Radhakrishnan100.34
Chaitanya Nutakki222.08
Bipin Nair32614.21
Shyam Diwakar44418.20