Title
Characterizing robustness and sensitivity of convolutional neural networks for quantitative analysis of mitochondrial morphology
Abstract
Quantitative analysis of mitochondrial morphology plays important roles in studies of mitochondrial biology. The analysis depends critically on segmentation of mitochondria, the image analysis process of extracting mitochondrial morphology from images. The main goal of this study is to characterize the performance of convolutional neural networks (CNNs) in segmentation of mitochondria from fluorescence microscopy images. Recently, CNNs have achieved remarkable success in challenging image segmentation tasks in several disciplines. So far, however, our knowledge of their performance in segmenting biological images remains limited. In particular, we know little about their robustness, which defines their capability of segmenting biological images of different conditions, and their sensitivity, which defines their capability of detecting subtle morphological changes of biological objects.
Year
DOI
Venue
2018
10.1007/s40484-018-0156-3
Quantitative Biology
Keywords
DocType
Volume
convolutional neural network,mitochondrial morphology,image segmentation,robustness,sensitivity
Journal
6
Issue
ISSN
Citations 
4
2095-4697
0
PageRank 
References 
Authors
0.34
0
3
Name
Order
Citations
PageRank
Xiaoqi Chai151.57
Qinle Ba201.35
Ge Yang310.74