Paper Info
Title
ODAL - A one-shot distributed algorithm to perform logistic regressions on electronic health records data from multiple clinical sites.
Abstract
Electronic Health Records (EHR) contain extensive information on various health outcomes and risk factors, and therefore have been broadly used in healthcare research. Integrating EHR data from multiple clinical sites can accelerate knowledge discovery and risk prediction by providing a larger sample size in a more general population which potentially reduces clinical bias and improves estimation and prediction accuracy. To overcome the barrier of patient-level data sharing, distributed algorithms are developed to conduct statistical analyses across multiple sites through sharing only aggregated information. The current distributed algorithm often requires iterative information evaluation and transferring across sites, which can potentially lead to a high communication cost in practical settings. In this study, we propose a privacy-preserving and communication-efficient distributed algorithm for logistic regression without requiring iterative communications across sites. Our simulation study showed our algorithm reached comparative accuracy comparing to the oracle estimator where data are pooled together. We applied our algorithm to an EHR data from the University of Pennsylvania health system to evaluate the risks of fetal loss due to various medication exposures.
Year
Venue
Keywords
2019
Biocomputing-Pacific Symposium on Biocomputing
birth outcomes,distributed computing,meta-analysis,multi-site analysis,pregnancy,prenatal,surrogate likelihood
DocType
ISSN
Citations 
Conference
2335-6936
0
PageRank 
References 
Authors
0.34
0
4
Name
Order
Citations
PageRank
Rui Duan144.90
Mary Regina Boland21008.63
Jason H. Moore31223159.43
Yong Chen4750118.44