Title
Extraction of time-varying spatio-temporal networks using parameter-tuned constrained IVA.
Abstract
Dynamic functional connectivity (dFC) analysis is an effective way to capture the networks that are functionally associated and continuously changing over the scanning period. However, these methods mostly analyze the dynamic associations across the activation patterns of the spatial networks while assuming that the spatial networks are stationary. Hence, a model that allows for the variability in both domains and reduces the assumptions imposed on the data provides an effective way for extracting spatio-temporal networks. Independent vector analysis is a joint blind source separation technique that allows for estimation of spatial and temporal features while successfully preserving variability. However, its performance is affected for higher number of datasets. Hence, we develop an effective two-stage method to extract time-varying spatial and temporal features using IVA, mitigating the problems with higher number of datasets while preserving the variability across subjects and time. The first stage is used to extract reference signals using group independent component analysis (GICA) that are used in a parameter-tuned constrained IVA (pt-cIVA) framework to estimate time-varying representations of these signals by preserving the variability through tuning the constraint parameter. This approach effectively captures variability across time from a largescale resting-state fMRI data acquired from healthy controls and patients with schizophrenia and identifies more functionally relevant connections that are significantly different among healthy controls and patients with schizophrenia, compared with the widely used GICA method alone.
Year
DOI
Venue
2019
10.1109/TMI.2019.2893651
IEEE transactions on medical imaging
Keywords
Field
DocType
Functional magnetic resonance imaging,Feature extraction,Estimation,Data models,Adaptation models,Blind source separation,Independent component analysis
Data modeling,Computer vision,Dimensionality reduction,Pattern recognition,Functional magnetic resonance imaging,Feature extraction,Independent component analysis,Artificial intelligence,Component analysis,Dynamic functional connectivity,Blind signal separation,Mathematics
Journal
Volume
Issue
ISSN
38
7
1558-254X
Citations 
PageRank 
References 
1
0.36
0
Authors
4
Name
Order
Citations
PageRank
Suchita Bhinge133.80
Rami Mowakeaa210.36
Vince D Calhoun32769268.91
Tulay Adali421116.65