Name
Title | ||
|---|---|---|
Tongue Coating'S Metabolic Markers In Dampness-Heat Syndrome Of Chronic Gastritis Patients |
Abstract | ||
|---|---|---|
Objective: The aim of the study was to investigate the characteristic index and metabolic markers of tongue coating in the patients with chronic gastritis (CG). Methods: From October 2014 to July 2015, 24 healthy volunteers and 60 patients with chronic gastritis (30 with the dampness-heat syndrome and 30 with non-dampness-heat syndrome) were enrolled in the study. The metabolites of tongue coating among three groups were measured by gas chromatography/mass spectrometry (GC/MS) method. Results: The characteristics of tongue coating were different among dampness-heat syndrome group, non-dampness-heat syndrome group and control group. The tongue coating was thicker and greasier of the patients with chronic gastritis in dampness-heat syndrome group. Three metabolic markers were detected in tongue coating by gas chromatography/mass spectrometry, accompanied with a retention time of 14.994955, 14.47272 and 7.190636 between the dampness-heat syndrome group and non-dampness-heat syndrome group. By searching the NIST2005 database, these three metabolic biomarkers identified as Cystathionine or 3,5-Di-t-butyl-4-hydroxybenzoic acid, ethyl ester; Pyroglutamic acid and Putrescine were closely correlated with the metabolic pathways of the dampness-heat syndrome. Conclusions: The tongue coating of chronic gastritis with dampness-heat syndrome was thicker and greasier. These three metabolites biomarker in dampness-heat syndrome of chronic gastritis may be associated with the synthesis and decomposition of amino acids, suggesting that the pathway of amino acid metabolism may mediate the dampness-heat syndrome of chronic gastritis. |
Year | DOI | Venue |
|---|---|---|
2018 | 10.1109/BIBM.2018.8621094 | PROCEEDINGS 2018 IEEE INTERNATIONAL CONFERENCE ON BIOINFORMATICS AND BIOMEDICINE (BIBM) |
Keywords | Field | DocType |
dampness-heat syndrome, chronic gastritis, GC/MS | Tongue coating,Pyroglutamic acid,Gastroenterology,Computer science,Amino acid,Internal medicine,Cystathionine beta synthase,Metabolic pathway,Biomarker (medicine),Metabolism,Bioinformatics,Chronic gastritis | Conference |
ISSN | Citations | PageRank |
2156-1125 | 0 | 0.34 |
References | Authors | |
0 | 11 | |
Name | Order | Citations | PageRank |
|---|---|---|---|
| Lijuan Wang | 1 | 0 | 0.34 |
| Weifei Zhang | 2 | 0 | 0.34 |
| Zhi Wang | 3 | 0 | 0.34 |
| Chunrong Guo | 4 | 0 | 0.34 |
| Xiaofang Zhou | 5 | 0 | 1.01 |
| Huiwen Wang | 6 | 29 | 14.15 |
| Xue Li | 7 | 2196 | 186.96 |
| Li Li | 8 | 235 | 35.19 |
| XiaoXue Li | 9 | 22 | 5.58 |
| Zhumei Sun | 10 | 0 | 0.34 |
| Fufeng Li | 11 | 3 | 2.11 |