Paper Info
Title
Dynamical differential expression (DyDE) reveals the period control mechanisms of the Arabidopsis circadian oscillator.
Abstract
The circadian oscillator, an internal time-keeping device found in most organisms, enables timely regulation of daily biological activities by maintaining synchrony with the external environment. The mechanistic basis underlying the adjustment of circadian rhythms to changing external conditions, however, has yet to be clearly elucidated. We explored the mechanism of action of nicotinamide in Arabidopsis thaliana, a metabolite that lengthens the period of circadian rhythms, to understand the regulation of circadian period. To identify the key mechanisms involved in the circadian response to nicotinamide, we developed a systematic and practical modeling framework based on the identification and comparison of gene regulatory dynamics. Our mathematical predictions, confirmed by experimentation, identified key transcriptional regulatory mechanisms of circadian period and uncovered the role of blue light in the response of the circadian oscillator to nicotinamide. We suggest that our methodology could be adapted to predict mechanisms of drug action in complex biological systems.
Year
DOI
Venue
2019
10.1371/journal.pcbi.1006674
PLOS COMPUTATIONAL BIOLOGY
DocType
Volume
Issue
Journal
15
1
ISSN
Citations 
PageRank 
1553-7358
0
0.34
References 
Authors
6
14
Name
Order
Citations
PageRank
Laurent Mombaerts100.34
Alberto Carignano200.34
Fiona C Robertson300.34
Timothy J Hearn400.34
Jin Junyang500.34
David P. Hayden6262.92
Zoe Rutterford700.34
Carlos T Hotta800.34
Katherine E Hubbard900.34
Marti Ruiz C Maria1000.34
Ye Yuan1120.73
Matthew A. Hannah12672.51
Goncalves, J.1340442.24
Alex A R Webb1400.34