Paper Info
Title
Effects Of Microgravity On Action Potential Wave Propagation In Rat Transmural Ventricle Tissue
Abstract
Experiments mimicking microgravity condition have multiple effects on cardiac elecfrophysiology. Therefore, based on experimental data of rats with 2-weeks (short term) and 4-weeks (long term) tail suspension, effect of microgravity on action potentials (APs) were simulated by decreasing I-CaL and increasing I-NaK based on rat endocardial and epicardial models. Additionally, a 1D model was constructed by considering the increasing of connexin 43 under microgravity condition. Simulation results show that I-CaL and I-NaK changes have similar effect in reducing APD(90) under short term condition, while the inhibition of I-CaL is the main factor in reducing APD(90) under long term condition. The simulated pseudo-ECG in both conditions showed a shortened QT interval and depressed of ST phase and T wave as experimental observations. Increased expression of connexin 43 in microgravity condition resulted in a mild increase in conduction velocity. Meanwhile, the vulnerable window in 1D ventricle strand reduced in microgravity condition. Compared with short term microgravity condition, all these changes were more prominent in the long term microgravity condition. In conclusion, this study provides new insight into understanding of impaired cardiac functions in short and long term microgravity conditions during spaceflight.
Year
DOI
Venue
2018
10.22489/CinC.2018.191
2018 COMPUTING IN CARDIOLOGY CONFERENCE (CINC)
Field
DocType
Volume
Connexin,Tail Suspension,Spaceflight,Nerve conduction velocity,Wave propagation,Biophysics,NAK,Cardiac electrophysiology,Ventricle,Physics
Conference
45
ISSN
Citations 
PageRank 
2325-8861
0
0.34
References 
Authors
0
6
Name
Order
Citations
PageRank
xiangyun bai102.03
Kuanquan Wang21617141.11
Qince Li379.91
Cunjin Luo418.06
Yacong Li505.07
Henggui Zhang610551.88