Paper Info
Title
Role Of I-F (Funny Current) On Biological Pacemaker - Insight From A Ventricular Model
Abstract
Biological pacemaker has been proposed as a promising alternative to electrical pacemaker for treating patients with impaired native cardiac pacemaker. It has been verified that overexpressing the hyperpolarization-activated funny channel current (funny current, Id can induce automatic pacing activities in ventricular myocytes (VMs). In this study, possible roles of I-f expression in generating automaticity in Ms are systematically investigated. We implemented a computational approach to study mechanism by which increase of I-f induces automaticity in Ms. The TP06 model of the electrical action potential in the human Ms was modified by incorporating I-f formulation. When the channel conductance of I-f was greater than 0.09 nS/pF, the Ms showed spontaneous pacing activities. During the time course of spontaneous action potentials, incorporating I-f induced changes in the intracellular ionic concentrations, leading to accumulation of intracellular calcium ([Ca2+](i)) as well as sodium concenfration ([Na+](i)), but a decrease in the intracellular potassium concenfration ([K+](i)). By clamping [Na+](i), and [K+](i) to a constant level, a fast and stable spontaneous pacemaking activity was observed. This study helps to understand the mechanism of creating biological pacemakers using I-f overexpression.
Year
DOI
Venue
2018
10.22489/CinC.2018.193
2018 COMPUTING IN CARDIOLOGY CONFERENCE (CINC)
DocType
Volume
ISSN
Conference
45
2325-8861
Citations 
PageRank 
References 
0
0.34
0
Authors
5
Name
Order
Citations
PageRank
Yacong Li105.07
Kuanquan Wang21617141.11
Qince Li379.91
xiangyun bai402.03
Henggui Zhang510551.88