Paper Info
Title
Effects Of Camkii Regulation On Atrial Action Potential Under Oxidative Stress Condition
Abstract
Previous studies have demonstrated that oxidative stress is closely associated with cardiac arrhythmias via altering electrical activity and intracellular calcium dynamics of cardiac myocytes. The present study developed a human atrial cell model including effects of oxidative stress by incorporating reactive oxygen species (ROS)-induced CaMKII activation and its downstream effects on different ionic channels. The CaMKII dynamics was mimicked by a novel 6-state Markov chain model, including both autophosphorylation and oxidation pathways of CaMKII activation. Simulation results show that highly activated CaMKII by massive ROS phosphorylated L-type Ca2+ current (I-CaL) and elevated intracellular calcium concentration, which eventually resulted in calcium overload in sarcoplasmic reticulum in the condition of oxidative stress. Meanwhile, calcium overload resulted in increase of calcium release and cytoplasmic calcium concentration, which triggered afterdepolarizations (DADs) by increasing the calcium extrusion via the Na+-Ca2+ exchanger (NCX) current. This study revealed effects of massive ROS on calcium cycling in atrial myocytes and shed lights on mechanisms of cardiac arrhythmias induced by oxidative stress.
Year
DOI
Venue
2018
10.22489/CinC.2018.170
2018 COMPUTING IN CARDIOLOGY CONFERENCE (CINC)
Field
DocType
Volume
Myocyte,Calcium in biology,Calcium,Biophysics,Afterdepolarization,Ca2+/calmodulin-dependent protein kinase,Chemistry,Oxidative stress,Reactive oxygen species,Atrial action potential
Conference
45
ISSN
Citations 
PageRank 
2325-8861
0
0.34
References 
Authors
0
6
Name
Order
Citations
PageRank
Haibo Sui100.68
Qince Li279.91
Kuanquan Wang31617141.11
Funebi Francis Ijebu400.68
Yongfeng Yuan5117.40
Henggui Zhang610551.88