Paper Info
Title
Role Of Interaction Network Topology In Controlling Microbial Population In Consortia
Abstract
Engineering microbial consortia is an important new frontier for synthetic biology given its efficiency in performing complex tasks and endurance to environmental uncertainty. Most synthetic circuits regulate populational behaviors via cell-to-cell interactions, which are affected by spatially heterogeneous environments. Therefore, it is important to understand the limits on controlling system dynamics and provide a control strategy for engineering consortia under spatial structures. Here, we build a network model for a fractional population control circuit in two-strain consortia, and characterize the cell-to-cell interaction network by topological properties, such as symmetry, locality and connectivity. Using linear network control theory, we relate the network topology to system output's tracking performance. We analytically and numerically demonstrate that the minimum network control cost for good tracking depends on locality difference between two cell population's spatial distributions and how strongly the controller node contributes to interaction strength. To realize a robust consortia, we can manipulate the environment to form a strongly connected network. Our results ground the expected cell population dynamics in its spatially organized interaction network, and inspire directions in cooperative control in microbial consortia.
Year
DOI
Venue
2018
10.1109/CDC.2018.8619704
2018 IEEE CONFERENCE ON DECISION AND CONTROL (CDC)
Field
DocType
ISSN
Topology,Population,Locality,Control theory,Telecommunications network,Biology,Network topology,System dynamics,Strongly connected component,Network model
Conference
0743-1546
Citations 
PageRank 
References 
0
0.34
0
Authors
2
Name
Order
Citations
PageRank
Xinying Ren111.64
Richard M. Murray2123221223.70