Paper Info
Title
3D choroid neovascularization growth prediction based on reaction-diffusion model
Abstract
Choroid neovascularization (CNV) is a kind of pathology from the choroid and CNV-related disease is one important cause of vision loss. It is desirable to predict the CNV growth rate so that appropriate treatment can be planned. In this paper, we seek to find a method to predict the growth of CNV based on 3D longitudinal Optical Coherence Tomography (OCT) images. A reaction-diffusion model is proposed for prediction. The method consists of four phases: preprocessing, meshing, CNV growth modeling and prediction. We not only apply the reaction-diffusion model to the disease region, but also take the surrounding tissues into consideration including outer retinal layer, inner retinal layer and choroid layer. The diffusion in these tissues is considered as isotropic. The finite-element-method (FEM) is used to solve the partial differential equations (PDE) in the diffusion model. The curve of CNV growth with treatment are fitted and then we can predict the CNV status in a future time point. The preliminary results demonstrated that our proposed method is accurate and the validity and feasibility of our model is obvious.
Year
DOI
Venue
2016
10.1117/12.2216188
Proceedings of SPIE
Keywords
Field
DocType
CNV growth prediction,reaction-diffusion model,FEM
Computer vision,Optical coherence tomography,Optics,Finite element method,Choroid,Artificial intelligence,Retinal,Neovascularization,Partial differential equation,Reaction–diffusion system,Diffusion (business),Physics
Conference
Volume
ISSN
Citations 
9788
0277-786X
0
PageRank 
References 
Authors
0.34
0
6
Name
Order
Citations
PageRank
Shuxia Zhu100.34
XinJian Chen250253.39
Fei Shi38612.91
Dehui Xiang49213.67
Weifang Zhu58515.92
Hao-Yu Chen69715.08