Paper Info
Title
CT guided diffuse optical tomography for breast cancer imaging
Abstract
Diffuse optical tomography (DOT) has attracted attentions in the last two decades due to its intrinsic sensitivity in imaging chromophores of tissues such as blood, water, and lipid. However, DOT has not been clinically accepted yet due to its low spatial resolution caused by strong optical scattering in tissues. Structural guidance provided by an anatomical imaging modality enhances the DOT imaging substantially. Here, we propose a computed tomography (CT) guided multispectral DOT imaging system for breast cancer detection. To validate its feasibility, we have built a prototype DOT imaging system which consists of a laser at wavelengths of 650 and an electron multiplying charge coupled device (EMCCD) camera. We have validated the CT guided DOT reconstruction algorithms with numerical simulations and phantom experiments, in which different imaging setup parameters, such as projection number of measurements, the width of measurement patch, have been investigated. Our results indicate that an EMCCD camera with air cooling is good enough for the transmission mode DOT imaging. We have also found that measurements at six projections are sufficient for DOT to reconstruct the optical targets with 4 times absorption contrast when the CT guidance is applied. Finally, we report our effort and progress on the integration of the multispectral DOT imaging system into a breast CT scanner.
Year
DOI
Venue
2016
10.1117/12.2216402
Proceedings of SPIE
Keywords
Field
DocType
Diffuse optical tomography,multi-modality imaging,breast cancer detection
Diffuse optical imaging,Multispectral image,Imaging phantom,Optics,Laser,Scanner,Charge-coupled device,Image resolution,Light scattering,Physics
Conference
Volume
ISSN
Citations 
9788
0277-786X
0
PageRank 
References 
Authors
0.34
0
4
Name
Order
Citations
PageRank
Reheman Baikejiang100.34
Wei Zhang27559.96
Dianwen Zhu301.01
Changqing Li412.10