Name
Abstract | ||
|---|---|---|
Chemotherapy is one of the most common approaches in cancer treatment. The problem with chemotherapy is that it does not only kill the cancerous cells, but the therapy affects badly the healthy cells as well. Accumulation of chemotherapy drugs with repeated doses in the patient's body leads to increasing toxicity in the whole body. This paper develops a general system dynamics model which clarifies the different factors affecting the treatment plans such as number of cancerous cells, drug accumulation, and toxicity. A stock and flow diagram is constructed to show the interaction of the system variables with each other. A simulation model using iThink software is used. The simulation results show a decreasing trend of the number of cancerous cells with repeated chemotherapy doses with time. On the other hand, the toxicity increases with time. Finally, sensitivity analysis is conducted to show the effect of doses cancellation and delay on the treatment efficacy. The results show that the model is more sensitive to doses cancellation than doses delay, thus cancelling doses is more critical on the patient's health than doses delaying. |
Year | DOI | Venue |
|---|---|---|
2016 | 10.1145/2908446.2908461 | INTERNATIONAL CONFERENCE ON INFORMATICS AND SYSTEMS (INFOS 2016) |
Keywords | DocType | Citations |
Chemotherapy, System Dynamics, Simulation, Stock and Flow | Conference | 0 |
PageRank | References | Authors |
0.34 | 1 | 2 |
Name | Order | Citations | PageRank |
|---|---|---|---|
| M. Heshmat | 1 | 0 | 0.34 |
| amr b eltawil | 2 | 4 | 8.52 |