Title
Capillary number effect on the depletion of leucocytes of blood in microfiltration chips for the isolation of circulating tumor cells
Abstract
To increase the purity of isolated circulating tumor cells (CTCs) in microfiltration chips, the depletion of leucocytes in human blood was systematically studied as a function of two dimensionless parameters, Capillary number Ca and the normalized leucocyte diameter. An optimized Ca* of 0.038 was identified to differentiate the capturing of cancer cells and leucocytes. Such Ca effect can be applied as a guideline for designing an optimized microfiltration system with both high capture efficiency and purity for isolating CTCs from human blood.
Year
DOI
Venue
2016
10.1109/NEMS.2016.7758264
2016 IEEE 11th Annual International Conference on Nano/Micro Engineered and Molecular Systems (NEMS)
Keywords
DocType
ISSN
circulating tumor cells,CTCs,Capillary number,leucocyte depletion,microfiltration
Conference
2474-3747
ISBN
Citations 
PageRank 
978-1-5090-1948-9
0
0.34
References 
Authors
0
10
Name
Order
Citations
PageRank
Cong Zhao100.68
Kui Song200.68
Jeng Hun Lee300.34
Shin Young Jeong400.34
Lixie Hu500.34
Xingsu Yu600.34
Huifang Su700.34
Zhenfeng Zhang800.34
Yitshak Zohar901.01
Yi-Kuen Lee10711.16