Paper Info
Title
A mathematical modeling research for effects of electric stimulus waveforms on the excitability of optic nerve fibers
Abstract
Visual prosthesis based on penetrative optic nerve (ON) stimulation is an alternative approach to partially restore visual function. As one of the most important factors, pulse shape of electrical stimulus is a major consideration in the design of ON visual prosthesis. Animal experiments showed that the evoked responses in visual cortex (V1) to ON electrical stimulation are dependent on the stimulus. The purpose of this research is to study the response properties of ON fibers under electrical stimulation in different shapes by mathematical modeling, in order to explore and explain the response mechanisms of ON to varied external electrical stimuli. Based on a mixed model of penetrating electrode and multiple ON fibers, we investigated the performance of a variety of stimulus waveforms in recruiting ON fiber responses by calculating recruitment area (RA). The simulation results provided a preliminary explanation for the V1 response properties to various ON electrical stimuli in the previous animal study. Besides, theoretical basis is formed for further design and choice of stimulus waveform in ON prosthesis.
Year
DOI
Venue
2017
10.1109/NER.2017.8008351
2017 8th International IEEE/EMBS Conference on Neural Engineering (NER)
Keywords
Field
DocType
mathematical modeling research,electric stimulus waveforms,optic nerve fiber excitability,visual prosthesis,penetrative optic nerve stimulation,visual function,pulse shape,ON visual prosthesis,evoked responses,visual cortex,ON electrical stimulation,varied external electrical stimuli,mixed model,penetrating electrode,multiple ON fibers,recruitment area,preliminary explanation,V1 response properties
Computer vision,Neuroscience,Communication,Visual cortex,Computer science,Waveform,Visual prosthesis,Pulse (signal processing),Artificial intelligence,Stimulus (physiology),Stimulation,Optic nerve
Conference
ISSN
ISBN
Citations 
1948-3546
978-1-5090-4604-1
0
PageRank 
References 
Authors
0.34
0
5
Name
Order
Citations
PageRank
Xinxin Li1278.16
Shirong Qiu211.64
Menghui Li300.34
Hong Guo43711.91
Liming Li552.68