Title
Monitoring ALS from speech articulation kinematics
Abstract
Patients affected by amyotrophic lateral sclerosis (ALS) show specific dysarthria in their speech resulting in specific marks which could be used to detect early symptoms and monitor the evolution of the disease in time. Classically articulation marks have been mainly based on static premises. Articulation kinematics from acoustic correlates may help in producing measurements depending on the dynamic behaviour of speech. Specifically, distribution functions from the absolute kinematic velocity estimated on a simplified articulation model can be used in establishing distances based on information theory concepts between running speech segments from patients and controls. As an example, several cases of ALS were studied longitudinally using this methodology. The study shows that the performance of dynamic articulation quality correlates may be sensitive and robust in tracking illness progress. Conclusions foresee the use of speech as a valuable monitoring methodology for ALS timely neurodegenerative progression.
Year
DOI
Venue
2020
10.1007/s00521-018-3538-6
Neural Computing and Applications
Keywords
DocType
Volume
Amyotrophic lateral sclerosis, Neuromotor diseases, Kullback–Leibler divergence, Speech articulation
Journal
32
Issue
ISSN
Citations 
20
1433-3058
0
PageRank 
References 
Authors
0.34
5
6
Name
Order
Citations
PageRank
Pedro Gómez111.06
Ana Rita Londral211230.69
Ana Rita Londral311230.69
Andrés Gómez411.06
Daniel Palacios501.01
V. Rodellar6147.98