Paper Info
Title
Comparative Modeling of Transcranial Magnetic and Electric Stimulation in Mouse, Monkey, and Human
Abstract
Transcranial magnetic stimulation (TMS) and transcranial electric stimulation (TES) are increasingly popular methods to noninvasively affect brain activity. However, their mechanism of action and dose-response characteristics remain under active investigation. Translational studies in animals play a pivotal role in these efforts due to a larger neuroscientific toolset enabled by invasive recordings. In order to translate knowledge gained in animal studies to humans, it is crucial to generate comparable stimulation conditions with respect to the induced electric field in the brain. Here, we conduct a finite element method (FEM) modeling study of TMS and TES electric fields in a mouse, capuchin and macaque monkeys, and a human model. We systematically evaluate the induced electric fields and analyze their relationship to head and brain anatomy. We find that with increasing head size, TMS-induced electric field strength first increases and then decreases according to a two-term exponential function. TES-induced electric field strength strongly decreases from smaller to larger specimen with up to 100x fold differences across species. Our results can serve as a basis to compare and match stimulation parameters across studies in animals and humans.
Year
DOI
Venue
2019
10.1016/j.neuroimage.2019.03.044
NeuroImage
Keywords
Field
DocType
Transcranial magnetic stimulation,Transcranial electric stimulation,Finite element modeling,Animal model,Neuromodulation
Animal studies,Neuroscience,Electric field,Biology,Transcranial magnetic stimulation,Brain anatomy,Brain activity and meditation,Bioinformatics,Stimulation
Journal
Volume
ISSN
Citations 
194
1053-8119
0
PageRank 
References 
Authors
0.34
0
4
Name
Order
Citations
PageRank
Ivan Alekseichuk111.16
Kathleen Mantell200.34
Sina Shirinpour300.68
Alexander Opitz4666.97