Name
Abstract | ||
|---|---|---|
The classic view establishing a unique site for AP initiation at the axon initial segment is not longer accepted. Different subregions of the neuron morphology may initiate and conduct APs, widening enormously the computational capabilities of individual neurons. The experimental investigation of non-linear dendritic properties is subject to error because of they are very sensitive to recording conditions. We used an experimentallyfitted compartmental model to examine the factors modulating the AP initiation site of hippocampal pyramidal neurons. Our results indicate that synchronous spatially clustered inputs initiate dendritic APs more effectively than equivalent disperse inputs. The average electrical distance from the dendritic input to the axon trigger zone also determines the initiation site, but it may be strongly modulated by a number of factors, such as the relative excitability of the two trigger zones. The computational meaning of the shifts in the AP initiation locus is discussed. |
Year | Venue | Keywords |
|---|---|---|
2003 | IWANN (1) | axon initial segment,non-linear dendritic property,neural computation,ap initiation site,unique site,initiation site,dendritic input,ap initiation locus,real neuron,axon trigger zone,dendritic aps,ap initiation,fault tolerant,computational neuroscience,cognitive process |
Field | DocType | Volume |
Computational neuroscience,Neuroscience,Trigger zone,Pattern recognition,Computer science,Models of neural computation,Axon,Artificial intelligence,Artificial neural network,Neuron,Hippocampal formation,Axon initial segment | Conference | 2686 |
ISSN | ISBN | Citations |
0302-9743 | 3-540-40210-1 | 0 |
PageRank | References | Authors |
0.34 | 1 | 1 |