Title
An agent-based genetically-aware entomological model
Abstract
There are multiple agent-based simulations investigating population and behavior dynamics of mosquito vectors. Some of these simulations model intervention pressures on the mosquito population to predict the impact of vector control strategies. These are complex models that can accurately characterize mosquitoes and simulate the effects of various interventions. One class of intervention methods involves the injection of altered genotypes into the vector population. The gene interrupts development and is inherited through the paternal line. Simulating these interventions requires an entomological model to be genetically-aware. We extend an existing model to capture genetic and heredity dynamics in a vector population. We show that it is possible to model heredity and simulate the effects of these intricate interventions through agent-based modeling. As a proof-of-concept, we simulate a method for insect control known as sterile insect technique (SIT). With our simulation, we show that introducing a female-specific lethal gene within the mosquito population greatly reduces the mosquito vector's ability to transmit malaria.
Year
Venue
Keywords
2011
SpringSim (ADS)
complex model,simulations model intervention pressure,model heredity,vector population,vector control strategy,existing model,mosquito population,entomological model,agent-based genetically-aware entomological model,agent-based modeling,mosquito vector,genetics,sterile insect technique
Field
DocType
ISBN
Econometrics,Population,Vector control,Agent-based model,Computer science,Sterile insect technique,Computational biology,Heredity
Conference
1-930638-56-6
Citations 
PageRank 
References 
0
0.34
2
Authors
3
Name
Order
Citations
PageRank
Regina McCormack100.34
James Gentile2243.72
Samuel S. C. Rund341.48