Title | ||
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Modified Surface Relief Layer Created by Holographic Lithography: Application to Selective Sodium and Potassium Sensing. |
Abstract | ||
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Point-of-care diagnostics will rely upon the development of low-cost, noncomplex, and easily integrated systems in order to examine biological samples such as blood and urine obtained from the patient. The development of metal ion sensors is a subject of significant relevance for physiological samples. The level of different blood electrolytes, mainly H+, Na+, K+ and Cl- is considerably used to monitor irregular physiologies. The particular challenge in biosensing, and in fact for any other sensor, is signal differentiation between non-specifically bound material and the specific detecting of the target molecule/ion. The biosensors described in this paper are fabricated by a holographic recording of surface relief structures in a photopolymer material. The surface structures are modified by coating with either dibenzo-18-crown-6 (DC) or tetraethyl 4-tert-butylcalix[4]arene (TBC), which are embedded in a polymer matrix. Interrogation of these structures by light allows indirect measurement of the concentration of the analyte. The influence of polymer matrices with different porosities, plasticised polyvinyl chloride (PVC) and a sol-gel matrix, on the performance of the sensors for detection of K+ and Na+ is examined. Here we demonstrate a proof of concept that by using a matrix with higher porosity one can increase the sensitivity of the sensor. The results showed that the DC sensing layer provides a selective response to K+ over Na+ and the TBC modified grating is more responsive to Na+ over K+. The sensor responds to K+ and Na+ within the physiological concentration ranges. |
Year | DOI | Venue |
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2019 | 10.3390/s19051026 | SENSORS |
Keywords | Field | DocType |
holographic sensors,diffractive optical sensors,biomedical sensors,sensors,holography,photopolymers,potassium ion detection,sodium ion detection,blood serum,PVC,sol gel | Analytical chemistry,Photopolymer,Polymer,Polyvinyl chloride,Porosity,Coating,Sodium,Sol-gel,Biosensor,Engineering | Journal |
Volume | Issue | ISSN |
19 | 5 | 1424-8220 |
Citations | PageRank | References |
0 | 0.34 | 0 |
Authors | ||
4 |
Name | Order | Citations | PageRank |
---|---|---|---|
Sabad-E Gul | 1 | 0 | 0.34 |
Luke A. O'Neill | 2 | 15 | 1.24 |
John Cassidy | 3 | 0 | 0.34 |
izabela naydenova | 4 | 0 | 0.68 |