Paper Info
Title
Abnormal Entropy Modulation of the EEG Signal in Patients With Schizophrenia During the Auditory Paired-Stimulus Paradigm.
Abstract
The complexity change in brain activity in schizophrenia is an interesting topic clinically. Schizophrenia patients exhibit abnormal task-related modulation of complexity, following entropy of electroencephalogram (EEG) analysis. However, complexity modulation in schizophrenia patients during the sensory gating (SG) task, remains unknown. In this study, the classical auditory paired-stimulus paradigm was introduced to investigate SG, and EEG data were recorded from 55 normal controls and 61 schizophrenia patients. Fuzzy entropy (FuzzyEn) was used to explore the complexity of brain activity under the conditions of baseline (BL) and the auditory paired-stimulus paradigm (S1 and S2). Generally, schizophrenia patients showed significantly higher FuzzyEn values in the frontal and occipital regions of interest (ROIs). Relative to the BL condition, the normalized values of FuzzyEn of normal controls were decreased greatly in condition S1 and showed less variance in condition S2. Schizophrenia patients showed a smaller decrease in the normalized values in condition S1. Moreover, schizophrenia patients showed significant diminution in the suppression ratios of FuzzyEn, attributed to the higher FuzzyEn values in condition S1. These results suggested that entropy modulation during the process of sensory information and SG was obvious in normal controls and significantly deficient in schizophrenia patients. Additionally, the FuzzyEn values measured in the frontal ROI were positively correlated with positive scores of Positive and Negative Syndrome Scale (PANSS), indicating that frontal entropy was a potential indicator in evaluating the clinical symptoms. However, negative associations were found between the FuzzyEn values of occipital ROIs and general and total scores of PANSS, likely reflecting the compensation effect in visual processing. Thus, our findings provided a deeper understanding of the deficits in sensory information processing and SG, which contribute to cognitive deficits and symptoms in patients with schizophrenia.
Year
DOI
Venue
2019
10.3389/fninf.2019.00004
FRONTIERS IN NEUROINFORMATICS
Keywords
Field
DocType
schizophrenia,electroencephalogram,fuzzy entropy,sensory gating,complexity
Sensory gating,Computer science,Brain activity and meditation,Positive and Negative Syndrome Scale,Artificial intelligence,Audiology,Stimulus (physiology),Sensory system,Cognition,Electroencephalography,Schizophrenia,Machine learning
Journal
Volume
ISSN
Citations 
13
1662-5196
1
PageRank 
References 
Authors
0.36
5
11
Name
Order
Citations
PageRank
Jie Xiang1537.00
Cheng Tian2100.99
Yan Niu310.70
Ting Yan410.36
Dandan Li5277.99
Rui Cao6131.73
Hao Guo7132.04
Xiaohong Cui8445.62
Huifang Cui910.36
Shuping Tan1061.51
Bin Wang1124614.34