Paper Info
Title
Determining Cutoff Point of Ensemble Trees Based on Sample Size in Predicting Clinical Dose with DNA Microarray Data.
Abstract
Background/Aim. Evaluating the success of dose prediction based on genetic or clinical data has substantially advanced recently. The aim of this study is to predict various clinical dose values from DNA gene expression datasets using data mining techniques. Materials and Methods. Eleven real gene expression datasets containing dose values were included. First, important genes for dose prediction were selected using iterative sure independence screening. Then, the performances of regression trees (RTs), support vector regression (SVR), RT bagging, SVR bagging, and RT boosting were examined. Results. The results demonstrated that a regression-based feature selection method substantially reduced the number of irrelevant genes from raw datasets. Overall, the best prediction performance in nine of 11 datasets was achieved using SVR; the second most accurate performance was provided using a gradient-boosting machine (GBM). Conclusion. Analysis of various dose values based on microarray gene expression data identified common genes found in our study and the referenced studies. According to our findings, SVR and GBM can be good predictors of dose-gene datasets. Another result of the study was to identify the sample size of n = 25 as a cutoff point for RT bagging to outperform a single RT.
Year
DOI
Venue
2016
10.1155/2016/6794916
COMPUTATIONAL AND MATHEMATICAL METHODS IN MEDICINE
Field
DocType
Volume
Data mining,Regression,Dna microarray data,Feature selection,Computer science,Support vector machine,Cutoff,Boosting (machine learning),Microarray gene expression,Sample size determination
Journal
2016
ISSN
Citations 
PageRank 
1748-670X
0
0.34
References 
Authors
5
3
Name
Order
Citations
PageRank
Selen Yilmaz Isikhan100.68
erdem karabulut202.03
Celal Reha Alpar300.34