Title
Models of temporal enhanced ultrasound data for prostate cancer diagnosis: the impact of time-series order.
Abstract
Recent studies have shown the value of Temporal Enhanced Ultrasound (TeUS) imaging for tissue characterization in transrectal ultrasound-guided prostate biopsies. Here, we present results of experiments designed to study the impact of temporal order of the data in TeUS signals. We assess the impact of variations in temporal order on the ability to automatically distinguish benign prostate-tissue from malignant tissue. We have previously used Hidden Markov Models (HMMs) to model TeUS data, as HMMs capture temporal order in time series. In the work presented here, we use HMMs to model malignant and benign tissues; the models are trained and tested on TeUS signals while introducing variation to their temporal order. We first model the signals in their original temporal order, followed by modeling the same signals under various time rearrangements. We compare the performance of these models for tissue characterization. Our results show that models trained over the original order-preserving signals perform statistically significantly better for distinguishing between malignant and benign tissues, than those trained on rearranged signals. The performance degrades as the amount of temporal-variation increases. Specifically, accuracy of tissue characterization decreases from 85% using models trained on original signals to 62% using models trained and tested on signals that are completely temporally-rearranged. These results indicate the importance of order in characterization of tissue malignancy from TeUS data.
Year
DOI
Venue
2017
10.1117/12.2255798
Proceedings of SPIE
Keywords
Field
DocType
Hidden Markov Models,Time-series,Ultrasound,Prostate Cancer,Tissue Characterization,Temporal Order
Computer vision,Ultrasonography,Pattern recognition,Biopsy,Malignancy,Prostate cancer,Artificial intelligence,Prostate,Medical diagnostics,Hidden Markov model,Ultrasound,Physics
Conference
Volume
ISSN
Citations 
10135
0277-786X
0
PageRank 
References 
Authors
0.34
4
12
Name
Order
Citations
PageRank
Layan Nahlawi121.83
Caroline Goncalves200.68
Farhad Imani393.44
Mena Gaed4258.08
Jose A Gomez5437.53
Madeleine Moussa6278.83
Eli Gibson718823.91
Aaron Fenster827067.27
Aaron D Ward98922.61
Purang Abolmaesumi10951111.52
Parvin Mousavi1136656.95
Hagit Shatkay1291096.13