Title
Multiscale Cross-Approximate Entropy Analysis of Bilateral Fingertips Photoplethysmographic Pulse Amplitudes among Middle-to-Old Aged Individuals with or without Type 2 Diabetes.
Abstract
Multiscale cross-approximate entropy (MC-ApEn) between two different physiological signals could evaluate cardiovascular health in diabetes. Whether MC-ApEn analysis between two similar signals such as photoplethysmographic (PPG) pulse amplitudes of bilateral fingertips can reflect diabetes status is unknown. From a middle-to-old-aged population free of prior cardiovascular disease, we selected the unaffected (no type 2 diabetes, n = 36), the well-controlled diabetes (glycated hemoglobin (HbA1c) < 8%, n = 30), and the poorly-controlled diabetes (HbA1c >= 8%, n = 26) groups. MC-ApEn indexes were calculated from simultaneous consecutive 1500 PPG pulse amplitudes signals of bilateral index fingertips. The average of scale factors 1-5 (MC-ApEnSS) and of scale factors 6-10 (MC-ApEnLS) were defined as the small-and large-scales MC-ApEn, respectively. The MC-ApEnLS index was highest in the unaffected, followed by the well-controlled diabetes, and then the poorly-controlled diabetes (0.70, 0.62, and 0.53; all paired p-values were < 0.05); in contrast, the MC-ApEnSS index did not differ between groups. Our findings suggested that the bilateral fingertips large-scale MC-ApEnLS index of PPG pulse amplitudes might be able to evaluate the glycemic status and detect subtle vascular disease in type 2 diabetes.
Year
DOI
Venue
2017
10.3390/e19040145
ENTROPY
Keywords
Field
DocType
multiscale cross-approximate entropy,photoplethysmographic wave amplitudes,type 2 diabetes
Diabetes mellitus,Population,Approximate entropy,Type 2 diabetes,Glycated hemoglobin,Pulse (signal processing),Vascular disease,Statistics,Mathematics,Glycemic
Journal
Volume
Issue
Citations 
19
4
3
PageRank 
References 
Authors
0.43
4
7
Name
Order
Citations
PageRank
Hsien-Tsai Wu124230.90
Cheng-Chan Yang281.39
Gen-Min Lin361.60
Bagus Haryadi461.60
Shiao-Chiang Chu560.93
Chieh-Ming Yang661.60
Cheuk-Kwan Sun76510.19