Paper Info
Title
Design and Performance of a Portable and Multichannel SPR Device.
Abstract
A portable multichannel surface plasmon resonance (SPR) biosensor device is presented in this study. As an optical biosensor device, the core component of its light path is a semi-cylindrical prism, which is used as the coupling unit for the excitation of the SPR phenomena. Based on this prism, a wedge-shaped incident light beam including a continuous angle range (10 degrees) is chosen to replace the commonly-used parallel light beam in traditional SPR devices, in which the incident angle is adjusted by a sophisticated mechanical system. Thus, complicated, cumbersome, and costly mechanical structures can be avoided in this design. Furthermore, the selection of a small and high-stability semiconductor laser and matrix CCD detector as well as a microfluidic system aids in the realization of a miniaturized and multichannel device. Several different samples were used to test the performance of this new device. For ethanol with different concentrations, the sensing response was of good linear relativity with the concentration (Y = 3.17143X + 2.81518, R-2 = 0.97661). Mouse IgG and goat anti-mouse IgG were used as biological samples for immunological analysis, and BSA as the control group. Good specific recognition between mouse IgG and goat anti-mouse IgG has been achieved. The detection limit of antibody to antigen coated on the sensing surface was about 25 mg/L without surface modification.
Year
DOI
Venue
2017
10.3390/s17061435
SENSORS
Keywords
Field
DocType
surface plasmon resonance,sensor,portability,microfluidic
Light beam,Analytical chemistry,Surface plasmon resonance,Coupling,Ray,Microfluidics,Electronic engineering,Laser,Engineering,Biosensor device,Detector
Journal
Volume
Issue
ISSN
17
6
1424-8220
Citations 
PageRank 
References 
0
0.34
0
Authors
8
Name
Order
Citations
PageRank
Xiao-ling Zhang100.34
Yan Liu22551189.16
Ting Fan300.34
Ning Hu401.01
Zhong Yang5202.29
Xi Chen622649.58
Zhen-yu Wang700.34
Jun Yang800.34